Using one-molecule optical and AFM imaging and drive-spectroscopy approaches, we seek out to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis interests involve:
1996, to start with mesoscopic cost density waves equipment; and 1st electrical measurements on only one metal nanocluster involving nanoelectrodes
Across the same time, the team of Paul McEuen, who was then primarily based at the College of California, Berkeley, showed similar success on ropes of bundled nanotubes. Depending upon the wrapping angle, nanotubes can can be found in metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed working with scanning tunnelling spectroscopy experiments.
Non-equilibrium folding of personal DNA molecules recaptured approximately one thousand periods in a very solid point out nanopore
2010, made a fresh way (‘wedging transfer’) to control nanostructures; initially report of DNA translocation as a result of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into reliable-point out nanopores
SMC complexes can pass physical roadblocks larger than their ring sizing, indicating a nontopological system for DNA loop extrusion
Numerous connected developments followed, in which our group proven different transistor variants like single-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into modest proof-of-theory electronic circuits.
Example (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in gray, the rim on the pore is highlighted in red, in addition to a 3D rendering in the movement in the DNA rod is exhibited.
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Right now, we also recognized that it should be achievable to utilize just one semiconducting carbon nanotube to produce a transistor — and we set out to really make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and utilised the underlying silicon substrate as being a gate electrode, establishing The essential 3-terminal layout of a field-outcome transistor (Fig.
[fourteen] In 2005 Dekker became involved with Netherlands-wide discussions about Clever Design and style, a motion that he has because Plainly distanced himself from. Dekker advocates that science and religion will not be in opposition but may be harmonized.
‘That fears the synthetic cell, as Element of the Dutch BaSyC initiative. Craig Venter looked top rated-down in These days and discovered about five hundred genes which might be minimally required for any operating mobile. We want to seem base-up: how do we transfer from the couple of molecules to a whole Organic procedure?
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
Sound-condition nanopores have verified to get a amazingly multipurpose probe for one-molecule Assessment of DNA. I'll explain a number of our modern results – exclusively DNA knots – and also our initiatives to grow the capabilities of strong-state nanopores even further, in the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.